Cortisol, also known as hydrocortisone, also known as hydrocorticoid or compound F(compound F), is extracted from the adrenal cortex and has the strongest effect on carbohydrate metabolism.
Cortisol is sometimes used exclusively to refer to the basic "stress hormone." Cortisol is produced from 11-deoxycortisol by the action of 11β-hydroxylase in the mitochondria of the adrenal cortex. Cortisol can also be converted to cortisol through the action of 11-β-hydroxysteroid dehydrogenase (11-β hydroxysteroid dehydrogena-se).
Normal cortisol metabolism follows this circadian rhythm, which is a 24-hour cycle. Generally, cortisol levels are highest in the morning (about 6-8 o'clock) and lowest in the early morning (about 0-2 o'clock). Cortisol levels typically drop sharply between 8:00 a.m. and 12:00 a.m., by a slow downward trend throughout the day. Cortisol levels start to rise again from their nadir around 2 a.m., leaving us awake and ready for a new stressful day. Breaking the pattern can cause cortisol levels to rise when they should be falling. People who experience repetitive stress, or have a stressful lifestyle, or are on a diet, or sleep less than 8 hours a night, are more likely to be chronically stressed, which can skew their cortisol levels over time. high. This is when the negative effects of cortisol begin to manifest as changes in metabolism: increased blood sugar, increased appetite, weight gain, decreased libido, and extreme fatigue.
If you have consistently high or low cortisol levels, it can have negative impacts on your overall health.
Cortisol is an essential hormone that affects almost every organ and tissue in your body. It plays many important roles, including:
Regulating your body's stress response.
Helping control your body's use of fats, proteins and carbohydrates, or your metabolism.
Suppressing inflammation.
Regulating blood pressure.
Regulating blood sugar.
Helping control your sleep-wake cycle.
Your body continuously monitors your cortisol levels to maintain steady levels (homeostasis). Higher-than-normal or lower-than-normal cortisol levels can be harmful to your health.
What does cortisol do?
Almost all tissues in the body have glucocorticoid receptors. Because of this, cortisol can affect nearly every organ system in thebody.
More specifically, cortisol affects your body in the following ways:
Regulating your body's stress response
Regulating metabolism
Suppressing inflammation
Regulating blood pressure
Increasing and regulating blood sugar
Helping control your sleep-wake cycle
What are the symptoms of high cortisol levels?
Common signs and symptoms of higher-than-normal cortisol levels include:
Weight gain, especially in your face and abdomen.
Fatty deposits between your shoulder blades.
Wide, purple stretch marks on your abdomen (belly).
Muscle weakness in your upper arms and thighs.
High blood sugar, which often turns into Type 2 diabetes.
High blood pressure (hypertension).
Excessive hair growth (hirsutism) in people assigned female at birth.
Weak bones (osteoporosis) and fractures.
What are the symptoms of low cortisol levels?
Symptoms of lower-than-normal cortisol levels, or adrenal insufficiency, include:
Fatigue.
Unintentional weight loss.
Poor appetite.
Low blood pressure (hypotension).
How do I check my cortisol levels?
Healthcare providers can quickly find out what cortisol levels are in your body with a lyophilised sphere Cortisol Test Kit(Chemiluminescence Immunoassay) from Poclight Bio, which they will use as a basis for their results and clinical judgement.
What’s the principal of Poclight biotechnology test kit?
Cortisol Test Kit(Chemiluminescence Immunoassay) adopts a homogeneous chemiluminescence competition method. Under the condition of alkaline hydrogen peroxide, acridinium ester (AE) is oxidized to an excited state, and a strong chemiluminescence signal is released when it returns to the ground state. The luminescence intensity of the reaction is detected by a luminescence signal measuring device, and the luminescence intensity is directly related to the Cortisol content in the sample.
More information please visit Poclight Cortisol Test Kit(Chemiluminescence Immunoassay).