Coagulation and Platelet Function Immunoassay Testing

Coagulation Function vs. Platelet Function

Coagulation function and platelet function are both related to blood clotting and hemostasis, but they operate through different mechanisms. In normal circumstances, the body maintains a dynamic balance between the coagulation and anticoagulation systems, which is crucial for preventing abnormal bleeding or thrombus formation. Imbalances in this equilibrium can result in bleeding or clot formation. In clinical practice, the coagulation panel and thrombosis panel are commonly used to assess the clotting capacity of blood and the functionality of the anticoagulation system.

Platelet function testing techniques

Platelet function testing primarily evaluates the functions of platelet aggregation, adhesion, and release. It is of significant importance in diagnosing hemorrhagic or thrombotic disorders, assessing platelet thrombotic risk, monitoring the efficacy of preventive and therapeutic antiplatelet medications, and ensuring the quality of transfused blood components. The testing techniques include platelet aggregation function testing, platelet adhesion function testing, and platelet activation function testing among others.

POClight POCT solution

Featured items - Chemiluminescence assay for detection of anti-platelet antibodies (homogeneous chemiluminescence), no separation and cleaning

Product Highlights - Platelet function testing Lyophilized reagents (no need for refrigerated storage and transportation), single packing

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Rapid: quantitative test results in as fast as 5 minutes, Platelet Functional Testing Via High-Throughput

Reliable: Whole blood or plasma, solve the problem of platelet activation in vitro, and truly reflect the activation status in vivo

Convenient: Use less blood volume, support lyophilization reagents

In recent years, the research progress in platelet function testing has primarily focused on improving the accuracy and convenience of the tests and exploring new biomarkers and methods. In clinical practice, the choice of testing method depends on factors such as laboratory conditions, the purpose of the test, required time, and cost. Currently, flow cytometry is a commonly used method, but it is complex to perform, with a lengthy experimental process (taking 6-8 hours, while actual operation time is 1-2 hours). Moreover, this method has high requirements for specimen storage and preparation, as well as considerations for specimen freshness and specific testing requirements, which limits its application.

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